Rome siblings, Coby Jarod Burley, 21, and Cassidy J Burley, 30, were arrested at their home on Lombardy Way after they got into a physical altercation.
Reports said that Coby pushed and punched his sister while Cassidy returned the hit before getting a knife and pointing it at her brother.
Both are charged with simple battery.
Cassidy is additionally charged with aggravated assault.